The influenza A virus NS1 protein inhibits activation of Jun N-terminal kinase and AP-1 transcription factors.
Identifieur interne : 002B39 ( Main/Exploration ); précédent : 002B38; suivant : 002B40The influenza A virus NS1 protein inhibits activation of Jun N-terminal kinase and AP-1 transcription factors.
Auteurs : Stephan Ludwig [Allemagne] ; Xiuyan Wang ; Christina Ehrhardt ; Hongyong Zheng ; Nicola Donelan ; Oliver Planz ; Stephan Pleschka ; Adolfo García-Sastre ; Gudrun Heins ; Thorsten WolffSource :
- Journal of virology [ 0022-538X ] ; 2002.
Descripteurs français
- KwdFr :
- ARN double brin, Activation enzymatique, Animaux, Cellules Vero, Chiens, Facteur de transcription AP-1 (métabolisme), JNK Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinases (métabolisme), Protéines virales non structurales (génétique), Protéines virales non structurales (métabolisme), Régulation de l'expression des gènes, Régulation négative, Régulation positive, Virus de la grippe A (génétique), Virus de la grippe A (métabolisme).
- MESH :
- génétique : Protéines virales non structurales, Virus de la grippe A.
- métabolisme : Facteur de transcription AP-1, Mitogen-Activated Protein Kinases, Protéines virales non structurales, Virus de la grippe A.
- ARN double brin, Activation enzymatique, Animaux, Cellules Vero, Chiens, JNK Mitogen-Activated Protein Kinases, Régulation de l'expression des gènes, Régulation négative, Régulation positive.
English descriptors
- KwdEn :
- Animals, Chlorocebus aethiops, Dogs, Down-Regulation, Enzyme Activation, Gene Expression Regulation, Influenza A virus (genetics), Influenza A virus (metabolism), JNK Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinases (metabolism), RNA, Double-Stranded, Transcription Factor AP-1 (metabolism), Up-Regulation, Vero Cells, Viral Nonstructural Proteins (genetics), Viral Nonstructural Proteins (metabolism).
- MESH :
- chemical , genetics : Viral Nonstructural Proteins.
- chemical , metabolism : Mitogen-Activated Protein Kinases, Transcription Factor AP-1, Viral Nonstructural Proteins.
- chemical : JNK Mitogen-Activated Protein Kinases, RNA, Double-Stranded.
- genetics : Influenza A virus.
- metabolism : Influenza A virus.
- Animals, Chlorocebus aethiops, Dogs, Down-Regulation, Enzyme Activation, Gene Expression Regulation, Up-Regulation, Vero Cells.
Abstract
The influenza A virus nonstructural NS1 protein is known to modulate host cell gene expression and to inhibit double-stranded RNA (dsRNA)-mediated antiviral responses. Here we identify NS1 as the first viral protein that antagonizes virus- and dsRNA-induced activation of the stress response-signaling pathway mediated through Jun N-terminal kinase.
DOI: 10.1128/jvi.76.21.11166-11171.2002
PubMed: 12368362
Affiliations:
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Le document en format XML
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Here we identify NS1 as the first viral protein that antagonizes virus- and dsRNA-induced activation of the stress response-signaling pathway mediated through Jun N-terminal kinase.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Düsseldorf</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Düsseldorf</li></settlement></list><tree><noCountry><name sortKey="Donelan, Nicola" sort="Donelan, Nicola" uniqKey="Donelan N" first="Nicola" last="Donelan">Nicola Donelan</name><name sortKey="Ehrhardt, Christina" sort="Ehrhardt, Christina" uniqKey="Ehrhardt C" first="Christina" last="Ehrhardt">Christina Ehrhardt</name><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name><name sortKey="Heins, Gudrun" sort="Heins, Gudrun" uniqKey="Heins G" first="Gudrun" last="Heins">Gudrun Heins</name><name sortKey="Planz, Oliver" sort="Planz, Oliver" uniqKey="Planz O" first="Oliver" last="Planz">Oliver Planz</name><name sortKey="Pleschka, Stephan" sort="Pleschka, Stephan" uniqKey="Pleschka S" first="Stephan" last="Pleschka">Stephan Pleschka</name><name sortKey="Wang, Xiuyan" sort="Wang, Xiuyan" uniqKey="Wang X" first="Xiuyan" last="Wang">Xiuyan Wang</name><name sortKey="Wolff, Thorsten" sort="Wolff, Thorsten" uniqKey="Wolff T" first="Thorsten" last="Wolff">Thorsten Wolff</name><name sortKey="Zheng, Hongyong" sort="Zheng, Hongyong" uniqKey="Zheng H" first="Hongyong" last="Zheng">Hongyong Zheng</name></noCountry><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Ludwig, Stephan" sort="Ludwig, Stephan" uniqKey="Ludwig S" first="Stephan" last="Ludwig">Stephan Ludwig</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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